ANTIBIOTICSFROMStreptomyces bottropensis PRODUCING ORGANISM, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES

Oligomycin antibiotics, 44-homooligomycin A (NK86-0279 II) and B (NK86-0279 I) are newly discovered antitumor antibiotics with the substitution of ethyl for methyl at carbon 26. They were isolated from the culture broth of Streptomyces bottropensis NK86-0279. The structure of these two compoundswas deduced by spectroscopic and X-ray crystallographic analyses. These antibiotics showedpotent antitumor activities against various tumor cells in vitro, and were active against Colon 26 carcinoma in vivo. Although they showed no activity at 1,000/zg/ml against Gram-positive and Gram-negative bacteria and yeast, they have antifungal activity. 171